The role of gene expression in evolutionary adaptation has been a subject of debate for over 40 years.cis‐regulation of transcription has been proposed to be the primary source of morphological novelty in evolution, though this is based on only a handful of examples. Recently the first genome‐wide studies of gene expression adaptation have been published, giving us an initial global view of this process. Systematic studies such as these will allow a number of key questions currently facing the field of (...) gene expression evolution to be addressed. (shrink)

This paper looks at the issue of consent from children and whether the test of Gillick competency, applied in medical and healthcare practice, ought to extend to participation in research. It is argued that the relatively broad usage of the test of Gillick competency in the medical context should not be considered applicable for use in research. The question of who would and could determine Gillick competency in research raises further concerns relating to the training of the researcher to make (...) such a decision as well as to the obvious issue of the researcher’s personal interest in the project and possibility of benefiting from the outcome. These could affect the judgment of Gillick competency if the researcher is charged with making this decision. The above notwithstanding, there are two exceptional research situations in which Gillick competency might be legitimately applied: when the research is likely to generate significant advantages for the participants while exposing them to relatively minor risks, and when it is likely to generate great societal benefit, pose minimal risks for the participants and yet raise parental objection. In both cases, to ensure that autonomy is genuinely respected and to protect against personal interest, Gillick competency should be assessed by an individual who has no interest or involvement in the research. (shrink)

This study throws new light on the composition of Boyle's Free Enquiry into the Vulgarly Receiv'd Notion of Nature ; it also draws more general conclusions about Boyle's methods as an author and his links with his context. Its basis is a careful study of the extant manuscript drafts for the work, and their relationship with the published editions. Section 2 describes Boyle's characteristic method of composition from the late 1650s onwards, involving the dictation of discrete sections of text to (...) amanuenses; it also assesses the effect this had on the structure and presentation of Boyle's writings. Section 3 considers the published text section by section and indicates which parts were written when; it also surveys unpublished draft material relating to the work. Section 4 places the work in context, considering the intellectual threats that Boyle sought to confront in it, both when he initially composed it in the 1660s and when he rewrote it c. 1680. It thus anchors him more precisely than hitherto in the intellectual debates of his day. (shrink)

Research on destructive leadership has largely focused on leader characteristics thought to be responsible for harmful organizational outcomes. Recent findings, however, demonstrate the need to examine important contextual factors underlying such processes. Thus, the present study sought to determine the effects of an organization's climate and financial performance, as well as the leader's gender, on subordinate perceptions of and reactions (i.e., whistle-blowing intentions) to aversive leadership, a form of destructive leadership based on coercive power. 302 undergraduate participants read through a (...) series of vignettes describing a fictional organization, its employees, and an aversive leader in charge of the company's sales department. They were then asked to envision themselves as subordinates of the leader and respond to several quantitative measures and open-ended questions. Consistent with Padilla and colleagues' (2007) toxic triangle theory, results suggest that both perceptions and reactions to aversive leadership depend on the three aforementioned factors. Specifically, aversive leaders were perceived more aversively and elicited greater whistle-blowing intentions in financially unstable organizations possessing climates intolerant of negative leader behavior. Moreover, female aversive leaders were perceived more aversively than their male counterparts under such conditions. Theoretical and practical implications as well as future research directions are also discussed. (shrink)

In this book, published in 1686, the scientist Robert Boyle attacked prevailing notions of the natural world which depicted 'Nature' as a wise, benevolent and purposeful being. Boyle, one of the leading mechanical philosophers of his day, believed that the world was best understood as a vast, impersonal machine, fashioned by an infinite, personal God. In this cogent treatise, he drew on his scientific findings, his knowledge of contemporary medicine and his deep reflection on theological and philosophical issues, arguing that (...) it was inappropriate both theologically and scientifically to speak of Nature as if it had a mind of its own: instead, the only true efficient causes of things were the properties and powers given to matter by God. As such, A Free Enquiry into the Vulgarly Received Notion of Nature represents one of the subtlest statements concerning the philosophical issues raised by the mechanical philosophy to emerge from the period of the scientific revolution. (shrink)

This handbook presents a comprehensive introduction to the core areas of philosophy of education combined with an up-to-date selection of the central themes. It includes 95 newly commissioned articles that focus on and advance key arguments; each essay incorporates essential background material serving to clarify the history and logic of the relevant topic, examining the status quo of the discipline with respect to the topic, and discussing the possible futures of the field. The book provides a state-of-the-art overview of philosophy (...) of education, covering a range of topics: Voices from the present and the past deals with 36 major figures that philosophers of education rely on; Schools of thought addresses 14 stances including Eastern, Indigenous, and African philosophies of education as well as religiously inspired philosophies of education such as Jewish and Islamic; Revisiting enduring educational debates scrutinizes 25 issues heavily debated in the past and the present, for example care and justice, democracy, and the curriculum; New areas and developments addresses 17 emerging issues that have garnered considerable attention like neuroscience, videogames, and radicalization. The collection is relevant for lecturers teaching undergraduate and graduate courses in philosophy of education as well as for colleagues in teacher training. Moreover, it helps junior researchers in philosophy of education to situate the problems they are addressing within the wider field of philosophy of education and offers a valuable update for experienced scholars dealing with issues in the sub-discipline. Combined with different conceptions of the purpose of philosophy, it discusses various aspects, using diverse perspectives to do so. Contributing Editors: Section 1: Voices from the Present and the Past: Nuraan Davids Section 2: Schools of Thought: Christiane Thompson and Joris Vlieghe Section 3: Revisiting Enduring Debates: Ann Chinnery, Naomi Hodgson, and Viktor Johansson Section 4: New Areas and Developments: Kai Horsthemke, Dirk Willem Postma, and Claudia Ruitenberg. (shrink)

This paper examines the legal and ethical aspects of traceback testing, a process in which patients who have been previously diagnosed with ovarian cancer are identified and offered genetic testing so that their family members can be informed of their genetic risk and can also choose to undergo testing. Specifically, this analysis examines the ethical and legal limits in implementing traceback testing in cases when the patient is deceased and can no longer consent to genetic testing.

There are three different degrees to which we may allow a systematic theory of the world to embrace the idea of relatedness—supposing realism about non-symmetric relations as a background requirement. (First Degree) There are multiple ways in which a non-symmetric relation may apply to the things it relates—for the binary case, aRb ≠ bRa. (Second Degree) Every such relation has a distinct converse—for every R such that aRb there is another relation R* such that bR*a. (Third Degree) Each one of (...) them applies in an order to the things it relates—with regard to the state that results from R's applying to a and b, either R applies to a first and b second, or it applies to b first and a second. Whereas the first degree is near-indubitable, embracing the second or third generates unwholesome consequences. The second degree embodies a commitment to the existence of a superfluity of distinct converses and states to which such relations give rise. The third degree embodies commitment to recherché facts of the matter about how the states that arise from the application of one non-symmetric relation compare to any other. It is argued that accounts that purport to offer an analysis of the first degree generate unwelcome second or third degree consequences. This speaks in favour of our adopting an account of the application of relations that's not an analysis at all, an account that takes the first degree as primitive. (shrink)

Do non‐symmetric relations apply to the objects they relate in an order? According to the standard view of relations, the difference between aRb and bRa obtaining, where R is non‐symmetric, corresponds to a difference in the order in which the non‐symmetric relation R applies to a and b. Recently Kit Fine has challenged the standard view in his important paper ‘Neutral Relations’ arguing that non‐symmetric relations are neutral, lacking direction or order. In this paper I argue that Fine cannot account (...) for the application of non‐symmetric relations to their relata; so far from being neutral, these relations are inherently directional. (shrink)

The present state of ethical theory and practice is disquieting. Objectivism, in all its varieties, is unconvincing, and subjectivism, hedonic or emotive, is intellectually incredible and socially intolerable. No one is ethically content—except the dogmatist and the sceptic, who act willy nilly with the exponents of “might-cum-persuasion makes right.” Can we find a happier middle region between these inhospitable poles? Perhaps the very limitations of human valuation will provide the ground that ethics requires. Let us begin by considering the conditions (...) which must hold if ethical action is to be possible: 1. Only if the agent can provide a justifying reason for his choice of action can he claim to act ethically. For ethical action is a species of purposive action, and to act purposively entails the ability to give justifying reasons for one's choice of action. . Thus ethical action presupposes putatively grounded ethical judgment. 2. Justifying reasons must be acknowledgeable by all competent judges, i.e. by all persons who are acquainted with all relevant knowledge of the nature and consequences of the alternative courses of action, allow as far as possible for congenital, cultural and idiosyncratic bias, are capable of sane and serious reflection, and are able to make survey of their experience and to draw conclusions from it. For the judgment “the action A is ethically preferable to its alternatives B ” entails “A ought to be done” which in turn entails “every competent judge is capable of acknowledging the ground of the judgment ‘A is ethically preferable to B’ and consequently would be able to set himself to perform A as an ethical act, .” We can assure ourselves of this requirement of acknowledgeability by observing that whenever we resolve, and not merely settle, an ethical disagreement, we have achieved not only a factual, predictive, valuational and attitudinal agreement between the disputants, but a joint acknowledgment of the ground of the ethical judgment. Without this, the agreement could not be said to be ethical, whether the judgment be right or wrong or neither, but merely an agreement to disagree, ethically. Unless ethical disagreement is in principle resolvable, ethical judgment is impossible, for we should be unable to claim that our choice ought to be acted upon. (shrink)

On 18–19 May 2018, a symposium was held in the Research Institute of Irish and Scottish Studies at the University of Aberdeen to commemorate the tenth anniversary of the death of Ronald W. Hepburn (1927–2008). The speakers at this event discussed Hepburn’s oeuvre from several perspectives. For this book, the collection of the revised versions of their talks has been supplemented by the papers of other scholars who were unable to attend the symposium itself. Thus this volume contains contributions from (...) eighteen notable scholars of different disciplines, ranging from contemporary aesthetics and art theory through to philosophical approaches to religion, education and social anthropology. It also includes a bibliography of Hepburn’s writings. The essays were first published in two special issues of the Journal of Scottish Thought, vols. 10–11 (2018–2019). -/- Ronald William Hepburn was born in Aberdeen on 16 March 1927. He went to Aberdeen Grammar School, then he graduated with an M.A. in Philosophy (1951) and obtained his doctorate from the University of Aberdeen (1955). His tutor at Aberdeen was Donald MacKinnon (1913– 1994), a Scottish philosopher and theologian, the author of A Study in Ethical Theory (1957) and The Problem of Metaphysics (1974). Hepburn taught as Lecturer at the Department of Moral Philosophy at Aberdeen (1956–60), and he was also Visiting Associate Professor of Philosophy at New York University (1959–60). He returned from the United States as Professor of Philosophy at Nottingham University. In 1964, he was appointed as a Chair in Philosophy at the University of Edinburgh and between 1965 and 1968 he was also Stanton Lecturer in the Philosophy of Religion at the University of Cambridge. From 1975 until his retirement in 1996, he held the Professorship of Moral Philosophy at Edinburgh. He died in Edinburgh on 23 December 2008. His philosophical interests ranged from theology and the philosophy of religion through moral philosophy and the philosophy of education to art theory and aesthetics. Notably, Hepburn is widely regarded as the founder of modern environmental and everyday aesthetics as a result of the influence of papers in the 1960s which pioneered a new approach to the aesthetics of the natural world. (shrink)

Each world faith tradition has its own distinctive relationship with science, and the science-religion dialogue benefits from a greater awareness of what this relationship is. In this book, members of the International Society for Science and Religion (ISSR) offer international and multi-faith perspectives on how new discoveries in science are met with insights regarding spiritual realities.The essays reflect the conviction that “religion and science each proceed best when they’re pursued in dialogue with each other, and also that our fragmented and (...) divided world would benefit more from a stronger dialogue between science and religion.” In Part One, George F. R. Ellis, John C. Polkinghorne, and Holmes Rolston III, each a Templeton Prize winner, discuss their views on why the science and religion dialogue matters. They are joined in Part Two by distinguished theologians Fraser Watts and Philip Clayton, who place the dialogue in an international context; John Polkinghorne’s inaugural address to the ISSR in 2002 is also included. In Part Three, five members of the ISSR look at the distinctive relationships of their faiths to science: •Carl Feit on Judaism •Munawar Anees on Islam •B.V. Subbarayappa on Hinduism •Trinh Xuan Thuan on Buddhism •Heup Young Kim on Asian Christianity George Ellis, the recently elected second president of ISSR, summarizes the contributions of his colleagues. Ronald Cole-Turner then concludes the book with a discussion of the future of the science and religion dialogue. (shrink)

Maughn Rollins Gregory and Meghan Jane Laverty’s Gareth B. Matthews, The Child’s Philosopher explores the Philosophy for Children movement, and the way the work of Gareth B. Matthews carried forward its key components. In this paper, I consider the impact of Matthews’ embeddedness within a Western philosophical tradition, even as he strives mightily to propose a broad-minded approach to P4C. I draw upon the work of Amasa Philip Ndofirepi to explore the tensions and possibilities in reconciling Western and non-Western approaches (...) to P4C. I argue that the social contexts of culture, ethnicity, and nationality can serve to broaden P4C curricula and pedagogy, making it fit for schools in a liberal democratic society. (shrink)

According to philosophical folklore Ramsey maintained three propositions in his famous 1925 paper “Universals”: (i) there is no subject-predicate distinction; (ii) there is no particular-universal distinction; (iii) there is no particular-universal distinction because there is no subject-predicate distinction. The ‘first generation’ of Ramsey commentators dismissed “Universals” because they held that whereas predicates may be negated, names may not and so there is a subject-predicate distinction after all. The ‘second generation’ of commentators dismissed “Universals because they held that the absence of (...) a merely linguistic distinction between subject and predicate does not provide any kind of reason for doubting that a truly ontological (i.e. non-linguistic) distinction obtains between particulars and universals. But both first and second-generation criticisms miss their marks because Ramsey did not maintain the three identified propositions. The failure of commentators to appreciate the point and purpose of the position Ramsey actually advanced in “Universals” results from (a) failing to consider the range of different arguments advanced there, (b) looking at “Universals” in isolation from Ramsey’s other papers and (c) failing to consider Ramsey’s writings in the context of the views that Russell and Wittgenstein held during the early 1920s. Seen from this wider perspective Ramsey arguments in “Universals” take on an altogether different significance. They not only anticipate important contemporary developments⎯the resurgence of Humeanism and the doctrine that the existence of universals can only be established a posteriori⎯but also point beyond them. (shrink)

The ways in which Wittgenstein was directly influenced by William James (by his early psychological work as well his later philosophy) have been thoroughly explored and charted by Russell B. Goodman. In particular, Goodman has drawn attention to the pragmatist resonances of the Wittgensteinian notion of hinge propositions as developedand articulated in the posthumously edited and published work, On Certainty. This paper attempts to extend Goodman’s observation, moving beyond his focus on James (specifically, James’s Pragmatism) as his pragmatist reference point. (...) It aims to articulate the affinity between Wittgenstein’s thought on the topic of certainty and that of the neglected pragmatist thinker, George Santayana. -/- The paper draws on Duncan Pritchard’s recent reading of Wittgenstein’s On Certainty in order to articulate the concept of certainty involved in the notion of hinge propositions. It identifies two important and related points of affinity between this Wittgensteinian line of thought on certainty and the line of thought on the same topic articulated in Santayana’s Scepticism and Animal Faith. The paper argues, firstly, that, both lines of thought reflect a pragmatist concept of certainty, according to which our most fundamental certainties are not conceived as purely theoretical objects of belief or knowledge but rather as thearational presuppositions of beliefs and practical action. Secondly, it examines the way inwhich the pragmatist concept of certainty functions, for the two thinkers as a response to scepticism. It argues that although the two thinkers’ responses are very different, they are mutually compatible and, together, point towards the possibility of a distinctively pragmatist response to scepticism, which involves an anti-epistemological model of the intimate relation of the human self to the world. (shrink)

Abstract:This article contextualizes the thought of the Zhuangzi 莊子 via the Classic of Poetry (Shijing 詩經), the most canonical textual tradition from the Warring States (fifth century to 221 b.c.e.) into the early imperial period. First, it reads the fantastical vignettes from the opening of chapter 1 "Free-and-Easy Wandering" (Xiaoyao you 逍遙遊), as parodies of Shi poetics. Second, it argues that the themes of "wandering" (you 遊) and "lodging" (yu 寓) stand as critical alternatives to the Shi preoccupation with homeward, (...) ruler-centric movements. Such connections open up new ways of understanding the development of Zhuangzian thought. (shrink)

This note responds to an interpretation of Mohist Canon and Explanation B 671 published by John Makeham some years ago. Makeham’s interpretation makes significant contributions to our understanding of this passage, especially in calling attention to problems with two influential previous interpretations, those of A. C. Graham and Chad Hansen.3 Yet his reading presents difficulties of its own, which I will attempt to rectify here.

Mohism was an ancient Chinese philosophical movement founded in the fifth century B.C.E. by the charismatic artisan Mozi, or "Master Mo." The Mohists advanced a consequentialist ethics that anticipated Western utilitarianism by more than two thousand years and developed fascinating logical, epistemological, and political theories that set the terms of philosophical debate in China for generations. They were the earliest thinkers to outline a just war doctrine and to explain the origin of government from a state of nature. Their epistemology (...) and psychology provide intriguing alternatives to contemporary Western mentalism. The Philosophy of the Mozi is an extensive study of Mohism that immerses readers in the Mohist worldview, situates the movement's rise and decline within Chinese history, and highlights its relevance to modern thought. (shrink)

As hunters, Sam and Dean kill monsters because such creatures pose a threat to the lives of innocent people. Sam and Dean are confronted with a complex array of moral issues in killing.Supernatural depicts hunters as ordinary people who know of the hidden supernatural evil that exists in the world and choose to spend their lives fighting it. Hunting, as the name suggests, involves tracking down these creatures and figuring out a way to destroy them. There are three fundamentally important (...) types of creatures in Supernatural: monsters, spirits, and demons. As hunters, Sam and Dean are motivated to kill monsters to defend innocent people from being victims of those monsters. As hunters, Sam and Dean follow typical rules of morality when dealing with people, but if they're warriors, those rules might change significantly. Warriors are bound by “Just War Theory,” which gives combatants special permissions for killing enemy combatants. (shrink)

Most philosophical discussion of the particle concept that is afforded by quantum field theory has focused on free systems. This paper is devoted to a systematic investigation of whether the particle concept for free systems can be extended to interacting systems. The possible methods of accomplishing this are considered and all are found unsatisfactory. Therefore, an interacting system cannot be interpreted in terms of particles. As a consequence, quantum field theory does not support the inclusion of particles in our ontology. (...) In contrast to much of the recent discussion on the particle concept derived from quantum field theory, this argument does not rely on the assumption that a particulate entity be localizable. (shrink)

Further arguments are offered in defence of the position that the variant of quantum field theory (QFT) that should be subject to interpretation and foundational analysis is axiomatic quantum field theory. I argue that the successful application of renormalization group (RG) methods within alternative formulations of QFT illuminates the empirical content of QFT, but not the theoretical content. RG methods corroborate the point of view that QFT is a case of the underdetermination of theory by empirical evidence. I also urge (...) caution in extrapolating interpretive conclusions about QFT from the application of RG methods in other contexts (e.g., condensed matter physics). This paper replies to criticisms advanced by David Wallace, but aims to be self-contained. (shrink)

The Mohist Canons are a set of brief statements on a variety of philosophical and other topics by anonymous members of the Mohist school , an influential philosophical, social, and religious movement of China's Warring States period (479-221 B.C.). [1] Written and compiled most likely between the late 4th and mid 3rd century B.C., the Canons are often referred to as the “later Mohist” or “Neo-Mohist” canons, since they seem chronologically later than the bulk of the Mohist writings, most of (...) which are probably from the mid-5th to the late 4th century. The.. (shrink)

Following the experimental discovery of the Higgs boson, physicists explained the discovery to the public by appealing to analogies with condensed matter physics. The historical root of these analogies is the analogies to models of superconductivity that inspired the introduction of spontaneous symmetry breaking into particle physics in the early 1960s. We offer a historical and philosophical analysis of the analogies between the Higgs model of the electroweak interaction and the Ginsburg-Landau and Bardeen-Cooper-Schrieffer models of superconductivity, respectively. The conclusion of (...) our analysis is that both sets of analogies are purely formal in virtue of the fact that they are accompanied by substantial physical disanalogies. In particular, the formal analogies do not map the temporal, causal, or modal structures of SSB in superconductivity to temporal, causal, or modal structures in the Higgs model. These substantial physical disanalogies mean that analogies to models of superconductivity cannot supply the basis for the physical interpretation of EW SSB; however, an appreciation of the contrast between the physical interpretations of SSB in superconductivity and the Higgs model does help to clarify some foundational issues. Unlike SSB in superconductivity, SSB in the Higgs sector of the Standard Model is neither a temporal nor a causal process. We discuss the implications for the `eating' metaphor for mass gain in the Higgs model. Furthermore, the distinction between the phenomenological GL model and the dynamical BCS model does not carry over to EW models, which clarifies the desiderata for so-called `dynamical' models of EW SSB. Finally, the development of the Higgs model is an illuminating case study for philosophers of science because it illustrates how purely formal analogies can play a fruitful heuristic role in physics. (shrink)

With this work J. B. Schneewind has provided the most comprehensive history of modern moral philosophy available in English. Beginning with the moral theology of the Reformation and ending with Kant, Schneewind’s book offers a panorama of moral philosophy that includes the early modern natural lawyers and their metaphysical critics, the British sentimentalists and their rationalist opponents, and a whole series of eighteenth-century attempts to develop a secular moral philosophy grounded in autonomous human reason and will. Despite its broader multinational (...) scope and its focus on ethics rather than epistemology, Schneewind’s book seems destined to replace Beck’s Early German Philosophy: Kant and his Predecessors, as culminating and summating the work of the next generation of scholars working within the historiographical canons of American Kantianism. (shrink)